F. Tokunaga

Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection

This study shows that optineurin deficiency leads to IFNβ overproduction and increased survival in mice during viral infection due to impaired autophagy.

OTUD1 deubiquitylase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

This study identifies OTUD1 as a deubiquitylase that suppresses NF-κB and KEAP1-mediated inflammatory and oxidative stress responses, while promoting antiviral pathways and ROS-associated cell death.