T. Sawasaki

OTUD1 deubiquitylase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

This study identifies OTUD1 as a deubiquitylase that suppresses NF-κB and KEAP1-mediated inflammatory and oxidative stress responses, while promoting antiviral pathways and ROS-associated cell death.

PLZF is a new substrate of CRBN with thalidomide and 5-hydroxythalidomide

The paper identifies PLZF as a CRBN substrate degraded by thalidomide and 5-hydroxythalidomide, linking it to teratogenesis.