Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis
T. Fabre, A. M. S. Barron, S. M. Christensen, S. Asano, M. H. Wadsworth, X. Chen, J. Wang, J. McMahon, F. J. Schlerman, A. White, K. M. Hart, K. Kravarik, A. J. Fisher, L. A. Borthwick, N. C. Henderson, , K. Dower
The paper identifies a fibrogenic macrophage subset linked to liver and lung fibrosis across species and shows that targeting specific cytokines reduces fibrosis in models.
bioRxiv · Jul 1, 2022 · PreprintImmunology