Author

L. A. Borthwick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. J. Fisher· 3 shared N. C. Henderson· 2 shared A. Andreasson· 1 shared A. Chhatwal· 1 shared A. M. S. Barron· 1 shared A. Nazgiewicz· 1 shared A. S. Loudon· 1 shared A. White· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

A. J. Fisher

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Author profile →

3 papers

Recent·Most cited

Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis

T. Fabre, A. M. S. Barron, S. M. Christensen, S. Asano, M. H. Wadsworth, X. Chen, J. Wang, J. McMahon, F. J. Schlerman, A. White, K. M. Hart, K. Kravarik, A. J. Fisher, L. A. Borthwick, N. C. Henderson, , K. Dower

The paper identifies a fibrogenic macrophage subset linked to liver and lung fibrosis across species and shows that targeting specific cytokines reduces fibrosis in models.

bioRxiv · Jul 1, 2022 · PreprintImmunology

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

P. S. Cunningham, P. Meijer, A. Nazgiewicz, S. G. Anderson, L. A. Borthwick, J. Bagnall, G. B. Kitchen, M. Lodyga, N. Begley, R. V. Venkateswaran, R. Shah, P. F. Mercer, H. J. Durrington, N. C. Henderson, K. Piper-Hanley, , J. Blaikley

This study identifies REVERBα as a regulator of pulmonary fibrosis by modulating circadian rhythms and integrin β1 focal adhesion formation in fibroblasts, with potential therapeutic implications.

bioRxiv · Sep 25, 2019Cell Biology

Transcriptional analysis identifies novel biomarkers associated with successful ex-vivo perfusion of human donor lungs

J. R. Ferdinand, M. I. Morrison, A. Andreasson, C. Charlton, A. Chhatwal, W. E. Scott, L. A. Borthwick, M. R. Clatworthy, A. J. Fisher

Transcriptional analysis of lungs during ex-vivo perfusion identifies CHIT1 and SCGB1A1 as potential biomarkers to distinguish transplantable from non-transplantable lungs.

bioRxiv · Apr 17, 2019 · PreprintPhysiology