Author

A. J. Fisher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

L. A. Borthwick· 3 shared N. C. Henderson· 2 shared A. Aivazidis· 1 shared A. Andreasson· 1 shared A. Chhatwal· 1 shared A. D. Troutman· 1 shared A. Filby· 1 shared A. Halavatyi· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersImmunology

L. A. Borthwick

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

J. T. H. Lee, S. N. Barnett, K. Roberts, H. Ashwin, L. Milross, J.-W. Cho, A. Huseynov, B. Woodhams, A. Aivazidis, T. Li, J. Majo, P. C. Guerrero, M. Lee, A. M. A. Miranda, Z. Jablonska, , O. A. Bayraktar

This study integrates single-cell and spatial transcriptomics with histopathology to identify cellular and molecular changes in lung alveolar damage during COVID-19 progression.

bioRxiv · Dec 20, 2023Pathology

Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis

T. Fabre, A. M. S. Barron, S. M. Christensen, S. Asano, M. H. Wadsworth, X. Chen, J. Wang, J. McMahon, F. J. Schlerman, A. White, K. M. Hart, K. Kravarik, A. J. Fisher, L. A. Borthwick, N. C. Henderson, , K. Dower

The paper identifies a fibrogenic macrophage subset linked to liver and lung fibrosis across species and shows that targeting specific cytokines reduces fibrosis in models.

bioRxiv · Jul 1, 2022 · PreprintImmunology

Muscle fiber type differences in nitrate and nitrite storage and nitric oxide signaling in rats

G. M. Long, D. A. Gray, A. D. Troutman, A. J. Fisher, M. B. Brown, A. R. Coggan

The paper measures nitrate and nitrite concentrations in fast-twitch and slow-twitch rat muscles, finding higher levels in slow-twitch muscles despite hypothesizing the opposite.

bioRxiv · Jun 1, 2020 · PreprintPhysiology

Multiomic and quantitative label-free microscopy-based analysis of ex vivo culture and TGFbeta1 stimulation of human precision-cut lung slices

M. M. Khan, D. Poeckel, A. Halavatyi, F. Stein, J. Vappiani, D. C. Sevin, C. Tischer, N. Zinn, J. D. Eley, N. S. Gudmann, T. Muley, H. Winter, A. J. Fisher, C. B. nanthakumar, G. Bergamini, R. Pepperkok

The paper uses multiomic and microscopy techniques to study fibrosis in human lung slices, showing increased collagen deposition with TGFbeta1 stimulation and a novel SHG-based method to quantify it.

bioRxiv · Dec 13, 2019Physiology

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

P. S. Cunningham, P. Meijer, A. Nazgiewicz, S. G. Anderson, L. A. Borthwick, J. Bagnall, G. B. Kitchen, M. Lodyga, N. Begley, R. V. Venkateswaran, R. Shah, P. F. Mercer, H. J. Durrington, N. C. Henderson, K. Piper-Hanley, , J. Blaikley

This study identifies REVERBα as a regulator of pulmonary fibrosis by modulating circadian rhythms and integrin β1 focal adhesion formation in fibroblasts, with potential therapeutic implications.

bioRxiv · Sep 25, 2019Cell Biology

Transcriptional analysis identifies novel biomarkers associated with successful ex-vivo perfusion of human donor lungs

J. R. Ferdinand, M. I. Morrison, A. Andreasson, C. Charlton, A. Chhatwal, W. E. Scott, L. A. Borthwick, M. R. Clatworthy, A. J. Fisher

Transcriptional analysis of lungs during ex-vivo perfusion identifies CHIT1 and SCGB1A1 as potential biomarkers to distinguish transplantable from non-transplantable lungs.

bioRxiv · Apr 17, 2019 · PreprintPhysiology