Cis-Regulatory Element Hijacking by Structural Variants Overshadows Higher-Order Topological Changes in Primary Prostate Cancer
J. R. Hawley, S. Zhou, C. Arlidge, G. Grillo, K. Kron, R. Hugh-White, T. van der Kwast, M. Fraser, P. C. Boutros, R. G. Bristow, M. Lupien
The paper shows that structural variants causing cis-regulatory element hijacking have a greater impact on gene expression than changes in three-dimensional chromatin topology in primary prostate cancer.
bioRxiv · Jan 5, 2021Cancer Biology