Author

L. Ruan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:wet-lab / biochemical assay· 2 Organism:yeast· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

R. Li· 3 shared J. Zhu· 2 shared Y. Wang· 2 shared A. Chang· 1 shared A. Liu· 1 shared A. Murison· 1 shared A. Tomaszewski· 1 shared B. A. Johns· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

R. Li

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Metabolic regulation of misfolded protein import into mitochondria

Y. Wang, L. Ruan, J. Zhu, X. Zhang, A. Chang, A. Tomaszewski, R. Li

This study shows that Snf1/AMPK inhibits misfolded protein import into mitochondria and promotes mitochondrial biogenesis under glucose starvation, protecting mitochondrial fitness in yeast and human cells.

eLife · Jun 20, 2024Peer-reviewedCell Biology

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

Y. Dong, B. A. Johns, L. Ruan, M. Zeineldin, A. Liu, S. Raychaudhuri, I. Chiu, J. Zhu, B. Smith, N. Zhao, P. Searson, S. Watanabe, M. Donowitz, T. C. Larman, R. Li

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.

Science Advances · Apr 5, 2024Peer-reviewedCell Biology

Trojan horse virus delivering CRISPR-AsCas12f1 controls plant bacterial wilt caused by Ralstonia solanacearum

S. Peng, Y. Xu, H. Qu, F. Nong, F. Shu, G. Yuan, L. Ruan, D. Zheng

This paper develops an engineered filamentous phage that delivers CRISPR-AsCas12f1 to target Ralstonia solanacearum's virulence gene hrpB, effectively controlling bacterial wilt in tobacco.

bioRxiv · Nov 29, 2023 · PreprintMicrobiology

GPI-anchored Gas1 protein regulates cytosolic proteostasis in yeast

Y. Wang, L. Ruan, R. Li

This study identifies Gas1's role in regulating cytosolic proteostasis through the MAGIC pathway and UPS in yeast.

bioRxiv · May 26, 2023 · PreprintCell Biology

Candidate cancer driver mutations in super-enhancers and long-range chromatin interaction networks

L. Wadi, L. Uuskula-Reimand, K. Isaev, S. Shuai, V. Huang, M. Liang, D. Thompson, Y. Li, L. Ruan, M. Paczkowska, M. Krassowski, I. Dzneladze, K. Kron, A. Murison, P. Mazrooei, , J. Reimand

The paper identifies 41 frequently mutated regulatory elements in cancer genomes, enriched in non-coding mutations and linked to gene expression control through chromatin interactions.

bioRxiv · Dec 19, 2017Cancer Biology