Author

I. Dzneladze

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

J. Reimand· 2 shared A. Fortuna· 1 shared A. He· 1 shared A. Murison· 1 shared A. Rashid· 1 shared A. T. Bahcheli· 1 shared C. A. Newell· 1 shared C. J. Guidos· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

J. Reimand

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Author profile →

3 papers

Recent·Most cited

Pan-cancer analysis of the ion permeome reveals functional regulators of glioblastoma aggression

A. T. Bahcheli, H.-K. Min, M. Bayati, W. Dong, A. Fortuna, H. Zhao, I. Dzneladze, J. Chan, X. Chen, K. Guevara-Hoyer, P. B. Dirks, X. Huang, J. Reimand

The paper identifies survival-associated ion permeome genes across 29 cancer types and shows their role in glioblastoma aggression through functional experiments.

bioRxiv · Apr 7, 2023Cancer Biology

INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

J. F. Woolley, K. Chen, G. T. Saffi, G. E. Genc, D. K. C. Lee, I. Dzneladze, R. He, J. T.-S. Chow, M. M. Gabra, M. H. Son, C. M. P. Melo, C. A. Newell, A. He, E. M. Schoof, S. Z. Xie, , L. Salmena

This study identifies INPP4B's role in promoting leukemic stem cell (LSC) survival by enhancing lysosome biogenesis, leading to poor AML prognosis and suggesting therapeutic targets.

bioRxiv · Mar 25, 2021 · PreprintCancer Biology

Candidate cancer driver mutations in super-enhancers and long-range chromatin interaction networks

L. Wadi, L. Uuskula-Reimand, K. Isaev, S. Shuai, V. Huang, M. Liang, D. Thompson, Y. Li, L. Ruan, M. Paczkowska, M. Krassowski, I. Dzneladze, K. Kron, A. Murison, P. Mazrooei, , J. Reimand

The paper identifies 41 frequently mutated regulatory elements in cancer genomes, enriched in non-coding mutations and linked to gene expression control through chromatin interactions.

bioRxiv · Dec 19, 2017Cancer Biology