K. L. Gould

Characterization of Pik1 function in fission yeast reveals its conserved role in lipid synthesis and not cytokinesis

This study shows Pik1 in fission yeast localizes to the trans-Golgi and contributes to PI4P synthesis but not cytokinesis.

From goal to outcome: analyzing the progression of biomedical sciences PhD careers in a longitudinal study using an expanded taxonomy

This study tracks biomedical sciences PhD careers over ten years, finding most students change career goals, fewer pursue postdocs, and first non-training positions predict long-term careers.

Fission yeast CK1 promotes DNA double-strand break repair through both homologous recombination and non-homologous end joining

This study shows that fission yeast CK1 orthologues Hhp1 and Hhp2 promote DNA double-strand break repair through both homologous recombination and non-homologous end joining by phosphorylating substrates like Arp8.

The fission yeast cytokinetic ring component Fic1 promotes septum formation

This study identifies Fic1 as a key protein promoting septum formation in fission yeast through interactions with Cdc15, Imp2, and Cyk3, independent of the Chs2 ortholog.

Autophosphorylation of the CK1 kinase domain regulates enzyme activity and function

This study identifies a conserved autophosphorylation mechanism in CK1 kinases that inhibits activity, with implications for disease and regulation.

Adaptor protein Bbc1 regulates localization of Wsp1 and Vrp1 during endocytic actin patch assembly

This study identifies Bbc1 as a regulator of Wsp1 and Vrp1 localization during endocytic actin patch assembly in S. pombe by disrupting Myo1 interactions.

Relief of the Dma1-mediated checkpoint requires Dma1 autoubiquitination and dynamic localization

This study shows that Dma1's transient removal from SPBs during anaphase B, driven by auto-ubiquitination, is essential for silencing the Dma1-dependent mitotic checkpoint in fission yeast.