This study uses electrical impedance measurements to monitor and predict intracellular delivery efficiency via porous substrate electroporation without fluorescent labels or imaging.

bioRxiv · Oct 17, 2023Bioengineering

Characterization of Pik1 function in fission yeast reveals its conserved role in lipid synthesis and not cytokinesis

A. H. Willet, L. A. Turner, J. S. Park, L. Ren, C. E. Snider, K. L. Gould

This study shows Pik1 in fission yeast localizes to the trans-Golgi and contributes to PI4P synthesis but not cytokinesis.

bioRxiv · Jul 24, 2023Cell Biology

Why the architecture of environmental fluctuation matters for fitness

J. S. Park, A. Felmy

The paper shows how non-random structures in environmental fluctuations affect fitness, using a demographic model to compare different fluctuation types.

bioRxiv · Apr 21, 2022 · PreprintEcology

Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua

S. Kim, G.-Y. Park, J. S. Park, J. Park, H. Hong, Y. Lee

This study shows that capicua (CIC) regulates thymic T cell development by controlling positive and negative selection and TCR signaling, preventing autoimmunity.

bioRxiv · Jul 11, 2021Immunology

Spatial genomics maps the structure, character and evolution of cancer clones

A. Lomakin, J. Svedlund, C. Strell, M. Gataric, A. Shmatko, J. S. Park, Y. S. Ju, S. Dentro, V. Kleshchevnikov, V. Vaskivskyi, T. Li, O. A. Bayraktar, L. Moore, S. Pinder, A. L. Richardson, , L. R. Yates

The paper develops a spatial genomics method to map cancer clone structure, character, and evolution across breast cancer progression stages.

bioRxiv · Apr 16, 2021 · PreprintCancer Biology

The first finding of lichen Solorina saccata at an algific talus slope in Korea

J. S. Park, K.-H. Kim, D.-K. Kim, C. S. Kim, S.-Y. Park, S.-O. Oh

This study reports the first lichen ecology investigation at an algific talus slope in Korea, identifying 27 lichen species, including the newly recorded Solorina saccata, and predicts its potential habitats in South Korea.

bioRxiv · Jul 22, 2019Ecology

Ecological and evolutionary patterns in the enigmatic protist genus Percolomonas (Heterolobosea; Discoba) from diverse habitats

D. V. Tikhonenkov, S. H. Jhin, Y. Eglit, K. Miller, A. Plotnikov, A. G. B. Simpson, J. S. Park

The paper analyzes 18S rRNA gene sequences from seven Percolomonas cosmopolitus-like strains from diverse salinities, revealing cryptic species and ecological specialization.

bioRxiv · Apr 17, 2019Microbiology

Cyclical environments drive variation in life history strategies: a general theory of cyclical phenology

J. S. Park

The paper develops a demographic framework to explain how life history strategies adapt to cyclical environments and shows how cyclicality affects fitness optimality across species.

bioRxiv · Jan 28, 2019Ecology