A. J. Lazar

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.

Microparticle-delivered Cxcl9 prolongs Braf inhibitor efficacy in melanoma

The paper shows that delivering Cxcl9 via microparticles enhances the effectiveness of BRAF inhibitors in melanoma by reducing minimal residual disease relapse.

Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing

The paper shows that dissociation methods bias transcriptomes in sarcoma single-cell and single-nucleus RNA-seq, and demonstrates computational correction of these biases.

The Androgen Receptor: A Therapeutic Target in Desmoplastic Small Round Cell Sarcoma

The paper shows that DSRCT is driven by the androgen receptor and responds to androgen deprivation therapy.

New cellular models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor

This study generates new cell lines for undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor to better study sarcomagenesis and develop therapies.

Cell-of-Origin Analysis of Metastatic Gastric Cancer Uncovers the Origin of Inherent Intratumor Heterogeneity and a Fundamental Prognostic Signature

This study uses single-cell RNA sequencing to analyze the origin of intra-tumoral heterogeneity in gastric cancer and identifies a prognostic gene signature.

Bivalent and Broad Chromatin Domains Regulate Pro-metastatic Drivers in Melanoma

The paper identifies bivalent chromatin states and broad H3K4me3 domains associated with pro-metastatic drivers in melanoma using ChIP-sequencing data from tumor samples and cell lines.