Author

P. Chuntova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

H. Okada· 4 shared A. Yamamichi· 3 shared T. Nejo· 3 shared M. Montoya· 2 shared T. Chen· 2 shared A. L. Mende· 1 shared A. Sundstrom· 1 shared B. Schwer· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersImmunology

H. Okada

Mutual co-authors in cluster

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4 papers

Recent·Most cited

IRF8-driven reprogramming of the immune microenvironment enhances anti-tumor adaptive immunity and reduces immunosuppression in murine glioblastoma

M. Montoya, S. A. Collins, P. Chuntova, T. S. Patel, T. Nejo, A. Yamamichi, N. Kasahara, H. Okada

This study shows that delivering IRF8 via retroviral vector reprograms myeloid cells in glioblastoma, enhancing anti-tumor immunity and reducing immunosuppression.

bioRxiv · Apr 2, 2024 · PreprintImmunology

Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment

R. Hatae, K. Kyewalabye, A. Yamamichi, T. Chen, S. Phyu, P. Chuntova, T. Nejo, L. S. Levine, M. H. Spitzer, H. Okada

This study shows that pretreating CAR-T cells with Metformin and Rapamycin improves their metabolic function and anti-glioma activity under hypoxic conditions in brain tumors.

bioRxiv · Nov 13, 2023Immunology

Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice

P. Chuntova, Y. Hou, R. Naka, Y. Goretsky, T. Nejo, G. Kohanbash, T. Chen, A. L. Mende, M. Montoya, A. Yamamichi, K. M. Downey, D. Diebold, J. Skinner, H.-E. Liang, B. Schwer, H. Okada

This paper develops a novel transgenic mouse model expressing EGFRvIII-CAR on T-cells to study CAR T-cell therapy in syngeneic glioblastoma models.

bioRxiv · Jan 31, 2021Immunology

Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastoma

E. F. Simonds, E. D. Lu, E. V. Liu, W. Tamaki, C. Rancan, J. Stultz, M. Sinha, L. K. McHenry, N. M. Nasholm, P. Chuntova, A. Sundstrom, V. Genoud, S. A. Shahani, L. D. Wang, c. brown, , M. Hellstrom

This study identifies immune evasion mechanisms in checkpoint blockade-refractory glioblastoma using deep immune profiling and shows that enhancing antigen presentation can improve immunotherapy response.

bioRxiv · Dec 1, 2020Cancer Biology