The Regulation of Nucleic Acid Vaccine Responses by the Microbiome
A. M. F. Johnson, K. Hager, M.-G. Alameh, P. Van, N. Potchen, K. Mayer-Blackwell, A. Fiore-Gartland, S. Minot, P. J. C. Lin, Y. K. Tam, D. Weissman, J. G. Kublin
This study shows the microbiome affects nucleic acid vaccine responses differently depending on the vaccine type, enhancing mRNA-LNP responses but suppressing DNA-prime/DNA-protein-boost responses.
bioRxiv · Feb 18, 2023Immunology