K. Mehta

Context-dependent acetylation of the virulence regulator PhoP accounts for carbon-source specific mycobacterial growth inhibition under acidic conditions

The paper shows that PhoP acetylation, influenced by acidic conditions and carbon sources, affects mycobacterial growth and virulence.

Phosphatidylinositol 3-phosphate mediates Arc capsids secretion through the multivesicular body pathway

This study identifies the endosomal-multivesicular body (MVB) pathway as the secretion route for Arc capsids, mediated by phosphatidylinositol-3-phosphate (PI3P).

Curcumin alleviates Arsenic trioxide-induced behavioural impairment, oxidative damage & morphological alterations in striatal region of mice brain

This study shows curcumin reduces arsenic trioxide-induced behavioral, oxidative, and morphological damage in mice striatal regions.

Dual functioning by the PhoR sensor is a key determinant to Mycobacterium tuberculosis virulence

This study identifies PhoR as a dual-function sensor kinase/phosphatase in M. tuberculosis, revealing its role in virulence through pH and salt sensing and regulation of the PhoP regulon.

Multiple mechanisms of self-association of chemokine receptors CXCR4 and CCR5 demonstrated by deep mutagenesis

This study identifies multiple mechanisms of self-association in CXCR4 and CCR5 using deep mutagenesis and BiFC screening, revealing distinct regions critical for dimerization and functional outcomes.

The evolution of regulatory elements in the emerging promoter variant strains of HIV-1

The paper identifies nine promoter-variant strains of HIV-1C in Indian patients, showing genetic diversity in transcription factor binding sites that may affect viral latency and reservoir characteristics.

Cortical tethering of mitochondria by the dynein anchor Mcp5 enables uniparental mitochondrial inheritance during fission yeast meiosis

The paper shows that Mcp5 anchors mitochondria to cell poles in fission yeast meiosis, leading to uniparental mitochondrial inheritance.

Association of mitochondria with microtubules inhibits mitochondrial fission by precluding Dnm1 assembly

The paper shows that mitochondrial-microtubule association inhibits fission by blocking Dnm1 assembly, linking microtubule dynamics to mitochondrial morphology.

Regulation of the error-prone DNA polymerase polκ by oncogenic signaling and its contribution to drug resistance

Cancer cells under stress from oncogene or mTOR inhibition dysregulate the error-prone DNA polymerase polκ, which contributes to drug resistance in melanoma cells.