P. Paul

p53 mediated regulation of LINE1 retrotransposon derived R-loops

This study shows p53 suppresses L1 retrotransposon-derived R-loops by recruiting repressive epigenetic marks and inhibiting activating marks, preventing DNA damage and inflammation.

Context-dependent acetylation of the virulence regulator PhoP accounts for carbon-source specific mycobacterial growth inhibition under acidic conditions

The paper shows that PhoP acetylation, influenced by acidic conditions and carbon sources, affects mycobacterial growth and virulence.

Characterization of Ralstonia pseudosolanacearum diversity and screening host resistance to manage bacterial wilt in South Asia

The paper surveys RSSC pathogens in Bangladesh and Nepal, characterizes their genetic diversity, and screens crop accessions for resistance to bacterial wilt.

Apposed networks of interacting TCRs and BCRs exhibiting mosaicked CDR3 sequences made of fixed junctional motifs

The paper identifies two networks of TCRβ and IGH clonotypes with conserved CDR3 sequences associated with over 63 diseases, suggesting evolutionary-conserved primordial antigen receptors.

Dual functioning by the PhoR sensor is a key determinant to Mycobacterium tuberculosis virulence

This study identifies PhoR as a dual-function sensor kinase/phosphatase in M. tuberculosis, revealing its role in virulence through pH and salt sensing and regulation of the PhoP regulon.

Uncovering the Environmental Conditions Required for Phyllachora maydis Infection and Tar Spot Development on Corn in the United States for Use as Predictive Models for Future Epidemics

Convergence of two global regulators to coordinate expression of essential virulence determinants of Mycobacterium tuberculosis

The paper identifies a regulatory mechanism where CRP and PhoP co-activate virulence genes in M. tuberculosis through protein-protein interactions and promoter recruitment.

A non-destructive approach for measuring rice panicle-level photosynthetic responses using 3D-image reconstruction

This paper develops a non-destructive method to measure rice panicle-level photosynthetic responses using 3D imaging and gas exchange analysis, revealing differential responses to heat stress between two rice genotypes.

Mycobacterium tuberculosis PhoP integrates stress response to intracellular survival by regulating cAMP level

The paper identifies PhoP's role in regulating cAMP levels in M. tuberculosis by repressing the PDE Rv0805, affecting stress response and intracellular survival.

Molecular connectivity between extra-cytoplasmic sigma factors and PhoP accounts for integrated mycobacterial stress response

This study investigates how PhoP interacts with sigma factors to regulate mycobacterial stress responses under different conditions, revealing distinct roles in pH and redox homeostasis.

PhenoImage: an open-source GUI for plant image analysis

PhenoImage is an open-source GUI tool for analyzing high-throughput plant phenotyping images, designed for users without programming skills.

SeedExtractor: an open-source GUI for seed image analysis

SeedExtractor is an open-source GUI tool for rapid and accurate seed size and color measurement across plant species, validated on rice with genome-wide association analysis.

PI-Plat: A high-resolution image-based 3D reconstruction method to estimate growth dynamics of rice inflorescence traits

The paper introduces PI-Plat, a 3D imaging method to estimate rice inflorescence growth dynamics, showing voxel count correlates with seed number and maturation rate.

RNA polymerases as moving barriers to condensin loop extrusion

This study quantitatively investigates how RNA polymerases interact with condensin loop extrusion, showing RNAPs act as steric barriers that impede the process, particularly in highly transcribed regions.