Author

P. R. Singh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. SARKAR· 2 shared V. Anil Kumar· 2 shared A. Singh· 1 shared B. Bamniya· 1 shared H. Goar· 1 shared H. Khan· 1 shared K. Mehta· 1 shared P. Paul· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

D. SARKAR

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dual functioning by the PhoR sensor is a key determinant to Mycobacterium tuberculosis virulence

P. R. Singh, H. Goar, P. Paul, K. Mehta, B. Bamniya, V. Anil Kumar, R. Bansal, H. Khan, S. Karthikeyan, D. SARKAR

This study identifies PhoR as a dual-function sensor kinase/phosphatase in M. tuberculosis, revealing its role in virulence through pH and salt sensing and regulation of the PhoP regulon.

bioRxiv · Apr 13, 2023 · PreprintMicrobiology

Mycobacterium tuberculosis methyltransferase perturbs host epigenetic programming to promote bacterial survival

P. R. Singh, V. Dadireddy, S. Udupa, S. Kalladi, S. Shee, S. Khosla, R. Rajmani, A. Singh, S. Ramakumar, V. Nagaraja

This study shows that Mtb methyltransferase Rv2067c modifies host histone H3K79 methylation, inhibiting apoptosis and enhancing necrosis to promote bacterial survival.

bioRxiv · Feb 24, 2023 · PreprintMicrobiology

Metabolic switching of Mycobacterium tuberculosis during hypoxia is controlled by the virulence regulator PhoP

P. R. Singh, V. Anil Kumar, D. Sarkar

This study shows that PhoP integrates hypoxia with nitrogen metabolism in Mtb, controlling metabolic switching during hypoxia and affecting bacterial growth.

bioRxiv · Nov 16, 2019Microbiology