Author

K. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. Jin· 2 shared M. Barth· 2 shared S. D. Robinson· 2 shared A. M. Misic· 1 shared A. O. Bergland· 1 shared A. Radziszewska· 1 shared A. Rosa· 1 shared A. S. F. Berry· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

J. Jin

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Author profile →

6 papers

Recent·Most cited

Evaluation of phantom doping materials in quantitative susceptibility mapping

P. Hooper, J. Jin, K. O'Brien, M. Tourell, S. D. Robinson, M. Barth

This study evaluates four phantom doping materials for quantitative susceptibility mapping (QSM) by measuring molar susceptibility and test-retest repeatability at 3T and 7T.

bioRxiv · Feb 18, 2024Biophysics

Deep-Learning-Enabled Differentiation between Intraprostatic Gold Fiducial Markers and Calcification in Quantitative Susceptibility Mapping

A. W. Stewart, J. Goodwin, M. Richardson, S. D. Robinson, K. O'Brien, J. Jin, M. Barth, S. Bollmann

This paper develops a deep learning model using QSM to differentiate gold fiducial markers from calcification in prostate cancer patients, achieving higher accuracy than conventional MRI methods.

bioRxiv · Oct 26, 2023 · PreprintPathology

Extracellular communication between brain cells through functional transfer of Cre mRNA

D. Rufino-Ramos, K. Leandro, P. Perdigao, K. O'Brien, M. Pinto, M. Santana, T. SOLINGE, S. Mahjoum, X. Breakefield, K. Breyne, L. Pereira de Almeida

The paper develops a method to track brain-derived extracellular vesicles (bdEVs) by using Cre mRNA and a reporter system, showing their functional transfer across the brain and bloodstream.

bioRxiv · Jan 29, 2023 · PreprintCell Biology

Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila

H. Machado, A. O. Bergland, R. Taylor, S. Tilk, E. Behrman, K. Dyer, D. Fabian, T. Flatt, J. Gonzalez, T. Karasov, I. Kozeretska, B. P. Lazzaro, T. Merritt, J. Pool, K. O'Brien, , D. Petrov

The paper identifies parallel seasonal allele frequency shifts in Drosophila melanogaster across North America and Europe, linking environmental conditions to genomic responses to selection.

bioRxiv · Feb 15, 2021 · PreprintEvolutionary Biology

Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

C. Deakin, G. Cornish, K. Ng, N. Faulkner, W. Bolland, V. Panova, J. Hope, A. Rosa, R. Harvey, S. Hussain, C. Earl, B. Jebson, M. Wilkinson, L. Marshall, K. O'Brien, , G. Kassiotis

The paper examines antibody responses to HCoV-OC43 and SARS-CoV-2 in children with autoimmune rheumatic diseases, finding stronger spike antibody responses and cross-reactivity despite immunosuppressive treatment.

bioRxiv · Feb 15, 2021 · PreprintImmunology

Remodeling of the maternal gut microbiome during pregnancy is shaped by parity

A. S. F. Berry, M. K. Pierdon, A. M. Misic, M. C. Sullivan, K. O'Brien, Y. Chen, R. N. Baldassano, T. D. Parsons, D. P. Beiting

This study shows that maternal parity influences gut microbiome changes during pregnancy and affects offspring microbiota composition in pigs.

bioRxiv · Dec 4, 2020Microbiology