Author

K. Rouault-Pierre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Philippe· 4 shared A. Rio-Machin· 2 shared K. Woodley· 2 shared P. Gallipoli· 2 shared S. C. James· 2 shared V. Dembitz· 2 shared A. Alfonso-Pierola· 1 shared A. Diaz-Mazkiaran· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

C. Philippe

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SCD inhibition eradicates AML displaying high de novo fatty acid desaturation and synergizes with chemotherapy

V. Dembitz, H. Lawson, R. Burt, C. Philippe, S. C. James, S. Atkinson, J. Durko, L. M. Wang, J. Campos, A. M. Magee, K. Woodley, M. J. Austin, A. Rio-Machin, P. Casado-Izquierdo, F. Bewicke-Copley, , P. Gallipoli

SCD inhibition induces AML cell death and synergizes with chemotherapy to prolong survival in murine AML models.

bioRxiv · Aug 2, 2023Cancer Biology

HNRNPA2B1 controls an unfolded protein response-related prognostic gene signature in prostate cancer

J. G. Foster, E. E. M. Gea, M. A. Labiba, C. A. Anene, J. Stockley, C. Philippe, M. Cereda, K. Rouault-Pierre, H. Y. Leung, C. Bessant, P. Rajan

This study identifies HNRNPA2B1 as a driver of an unfolded protein response-related gene signature linked to poor prognosis in prostate cancer.

bioRxiv · Jun 21, 2022 · PreprintCancer Biology

Mannose metabolism inhibition sensitizes acute myeloid leukemia cells to cytarabine and FLT3 inhibitor therapy by modulating fatty acid metabolism to drive ferroptotic cell death.

K. Woodley, L. S. Dillingh, G. Giotopoulos, P. Madrigal, K. M. Rattigan, C. Philippe, V. Dembitz, A. S. M. Magee, R. Asby, L. N. van de Lagemaat, C. Mappereley, S. C. James, J. H. Prehn, K. Tzelepis, K. Rouault-Pierre, , P. Gallipoli

This study shows that inhibiting mannose metabolism sensitizes AML cells to cytarabine and FLT3 inhibitors by promoting ferroptotic cell death through fatty acid metabolism changes.

bioRxiv · May 16, 2022Cancer Biology

Transcriptional regulation of HSCs in Aging and MDS reveals DDIT3 as a Potential Driver of Dyserythropoiesis

N. Berastegui, M. Ainciburu, J. P. Romero, A. Alfonso-Pierola, C. Philippe, A. Vilas-Zornoza, P. San Martin, R. Ordonez, D. O. Alignani, S. Sarvide, L. Castro, J. M. Lamo-Espinosa, M. San-Julian, T. Jimenez, F. Lopez Cardenas, , F. Prosper

This study identifies DDIT3 as a driver of dyserythropoiesis in MDS by showing its upregulation in HSCs and its ability to disrupt erythropoiesis when overexpressed.

bioRxiv · Sep 8, 2021 · PreprintCancer Biology