Author

K. T. O'Toole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

M. McMahon· 2 shared B. D. Smith· 1 shared C. G. Kinsey· 1 shared C. M. Stehn· 1 shared D. A. Kircher· 1 shared D. H. Lum· 1 shared D. L. Flynn· 1 shared E. Snyder· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

M. McMahon

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2 papers

Recent·Most cited

Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

M. McMahon, P. C. Ghazi, K. T. O'Toole, S. Srinivas Boggaram, M. T. Scherzer, M. R. Silvis, Y. Zhang, M. Bogdan, B. D. Smith, G. Lozano, D. L. Flynn, E. Snyder, C. G. Kinsey

This study shows that combining ULK1/2 inhibition with KRASG12C inhibitors reduces lung cancer growth in preclinical models.

bioRxiv · Feb 6, 2024Cancer Biology

Genetic silencing of AKT induces melanoma cell death

G. L. Parkman, T. Turapov, D. A. Kircher, W. J. Burnett, C. M. Stehn, K. T. O'Toole, R. Flaherty, R. C. Elmer, K. M. Culver, M. Foth, R. Andtbacka, D. H. Lum, R. L. Judson-Torres, M. W. VanBrocklin, S. L. Holmen, M. McMahon

This study shows that genetic silencing of AKT paralogs in melanoma cells leads to cell death via mTORC signaling disruption, which can be rescued by activated SGK1, suggesting dual targeting of AKT and SGK1 as a potential therapy.

bioRxiv · Aug 15, 2022 · PreprintCancer Biology