M. W. VanBrocklin

Human Rhinoviruses: a novel class of oncolytic virus

This study investigates wild-type human rhinoviruses (HRVs) as oncolytic viruses, showing their ability to kill cancer cells and induce tumor regression in vitro and in vivo.

Genetic silencing of AKT induces melanoma cell death

This study shows that genetic silencing of AKT paralogs in melanoma cells leads to cell death via mTORC signaling disruption, which can be rescued by activated SGK1, suggesting dual targeting of AKT and SGK1 as a potential therapy.

Bidirectional interconversion between mutually exclusive tumorigenic and drug-tolerant melanoma cell phenotypes

This study identifies bidirectional interconversion between tumorigenic and drug-tolerant melanoma cell states through BRN2 expression, revealing distinct molecular programs and therapeutic implications.

BRAFV600E induces reversible mitotic arrest in human melanocytes via microRNA-mediated suppression of AURKB.

This study identifies microRNA-mediated suppression of AURKB as a mechanism by which BRAFV600E induces reversible mitotic arrest in human melanocytes, contributing to nevus formation.