Author

M. R. Silvis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:E. coli· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

K. L. Trotta· 2 shared S. Chou· 2 shared B. D. Smith· 1 shared B. M. Hayes· 1 shared B.-M. Koo· 1 shared C. A. Gross· 1 shared C. E. Dodd· 1 shared C. G. Kinsey· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

K. L. Trotta

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

M. McMahon, P. C. Ghazi, K. T. O'Toole, S. Srinivas Boggaram, M. T. Scherzer, M. R. Silvis, Y. Zhang, M. Bogdan, B. D. Smith, G. Lozano, D. L. Flynn, E. Snyder, C. G. Kinsey

This study shows that combining ULK1/2 inhibition with KRASG12C inhibitors reduces lung cancer growth in preclinical models.

bioRxiv · Feb 6, 2024Cancer Biology

Lipopolysaccharide integrity primes bacterial sensitivity to a cell wall-degrading intermicrobial toxin

K. L. Trotta, B. M. Hayes, J. P. Schneider, J. Wang, H. Todor, P. Rockefeller Grimes, Z. Zhao, W. Hatleberg, M. R. Silvis, R. Kim, B.-M. Koo, M. Basler, S. Chou

The paper identifies genes in Escherichia coli that affect susceptibility to a cell wall-degrading toxin from Pseudomonas aeruginosa, revealing the role of lipopolysaccharide in modulating toxin toxicity.

bioRxiv · Jan 20, 2023 · PreprintMicrobiology

Ceragenins and antimicrobial peptides kill bacteria through distinct mechanisms

G. Mitchell, M. R. Silvis, K. C. Talkington, J. M. Budzik, C. E. Dodd, J. M. Paluba, E. A. Oki, K. L. Trotta, D. J. Licht, D. Jimenez-Morales, S. Chou, P. B. Savage, C. A. Gross, M. A. Marletta, J. S. Cox

This study compares the mechanisms of action of cationic antimicrobial peptides and ceragenins, finding distinct bacterial responses despite some overlapping effects.

bioRxiv · Oct 20, 2020Microbiology