Sphingosine kinases promote Ebola virus infection and can be targeted to inhibit filoviruses, coronaviruses, and arenaviruses using late endocytic trafficking to enter cells
C. M. Stewart, Y. Bo, K. Fu, M. Chan, R. Kozak, K. Y.-P. Apperley, G. Laroche, A. Beauchemin, G. Kobinger, D. Kobasa, M. Cote
This study shows that sphingosine kinases (SKs) facilitate entry of late-penetrating viruses like Ebola and SARS-CoV-2 by promoting endocytic trafficking, and their inhibition blocks viral entry.
bioRxiv · Aug 12, 2022Microbiology