Author
D. Kobasa
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2020-2023 · peak 5/yrCo-Author Collaboration Network
10 top collaborators · 33 mutual co-author links9 papers
Recent·Most cited
Sphingosine kinases promote Ebola virus infection and can be targeted to inhibit filoviruses, coronaviruses, and arenaviruses using late endocytic trafficking to enter cells
C. M. Stewart, Y. Bo, K. Fu, M. Chan, R. Kozak, K. Y.-P. Apperley, G. Laroche, A. Beauchemin, G. Kobinger, D. Kobasa, M. Cote
This study shows that sphingosine kinases (SKs) facilitate entry of late-penetrating viruses like Ebola and SARS-CoV-2 by promoting endocytic trafficking, and their inhibition blocks viral entry.
bioRxiv · Aug 12, 2022Microbiology
Development and Characterization of Recombinant Vesicular Stomatitis Virus (rVSV)-based Bivalent Vaccine Against COVID-19 Delta Variant and Influenza Virus
Z. Ao, M. Jing Ouyang, T. A. Olukitibi, B. Warner, R. Vendramelli, T. Truong, M. Zhang, S. Kung, K. R. Fowke, D. Kobasa, X. Yao
This study develops and tests a bivalent rVSV vaccine targeting SARS-CoV-2 Delta and influenza, showing strong immune responses and protection in animal models.
bioRxiv · Dec 14, 2021 · PreprintMicrobiology
Single immunization with recombinant ACAM2000 vaccinia viruses expressing the spike and the nucleocapsid proteins protect hamsters against SARS-CoV-2 caused clinical disease
J. Cao, Y. Deschambault, J. Lynch, B. Warner, K. Tierney, D. Huynh, R. Vendramelli, N. Tailor, S. Booth, B. Sajesh, K. Frost, K. LeBlanc, C. Layne, L. Lin, D. Beniac, , D. Kobasa
This study shows that a single immunization with a vaccinia virus expressing both SARS-CoV-2 spike and nucleocapsid proteins protects hamsters better than expressing either protein alone.
bioRxiv · Dec 2, 2021Microbiology
Development and characterization of influenza M2 ectodomain and/or HA stalk-based DC-targeting vaccines for different influenza infections
X. Yao, T. Olukitibi, Z. Ao, H. Azizi, M. Mahmoudi, K. Coombs, D. Kobasa, G. Kobinger
This study develops and tests DC-targeting influenza vaccines based on EboGP domains, showing they induce strong antibody responses and protect mice against H1N1 and H3N2 influenza.
bioRxiv · Oct 7, 2021 · PreprintMicrobiology
Exposure route, sex, and age influence disease outcome in a golden Syrian hamster model of SARS-CoV-2 infection
B. D. Griffin, B. M. Warner, M. Chan, E. J. Mendoza, N. Tailor, L. Banadyga, A. Leung, S. He, A. S. Boese, J. Audet, W. Cao, E. Moffat, L. Garnett, K. Tierney, K. N. Tran, , D. Kobasa
This study investigates how exposure route, sex, and age affect SARS-CoV-2 pathogenesis in golden Syrian hamsters, finding significant differences in disease outcomes.
bioRxiv · Jun 12, 2021 · PreprintMicrobiology
LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants
K. Westendorf, S. Zentelis, L. Wang, D. Foster, P. Vaillancourt, M. Wiggin, E. Lovett, R. van der Lee, J. Hendle, A. Pustilnik, J. M. Sauder, L. Kraft, Y. Hwang, R. W. Siegel, J. Chen, , Ramamurt
This paper identifies LY-CoV1404, a potent SARS-CoV-2 neutralizing antibody effective against multiple variants, including Omicron and Delta, due to its conserved epitope and resistance to common mutations.
bioRxiv · Apr 30, 2021Immunology
Prunella vulgaris extract and suramin block SARS-coronavirus 2 virus Spike protein D614 and G614 variants mediated receptor association and virus entry in cell culture system
Z. Ao, M. Chan, M. J. Ouyang, T. A. Olukitibi, M. Mahmoudi, D. Kobasa, X. Yao
This study shows that Prunella vulgaris extract and suramin inhibit SARS-CoV-2 Spike protein-mediated virus entry and reduce cytopathic effects in cell cultures.
bioRxiv · Aug 28, 2020 · PreprintMicrobiology
North American deer mice are susceptible to SARS-CoV-2
B. D. Griffin, M. Chan, N. Tailor, E. J. Mendoza, A. Leung, B. M. Warner, A. T. Duggan, E. Moffat, S. He, L. Garnett, K. N. Tran, L. Banadyga, A. Albietz, K. Tierney, J. Audet, , D. Kobasa
This study shows North American deer mice can be infected and transmit SARS-CoV-2, suggesting they may serve as a potential reservoir for the virus.
bioRxiv · Jul 25, 2020Microbiology