Author

C. M. Stewart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Immunology· 2 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

E. L. Siegler· 2 shared G. Laroche· 2 shared I. Can· 2 shared K. Fu· 2 shared K. Yun· 2 shared M. Cote· 2 shared R. L. Sakemura· 2 shared S. S. Kenderian· 2 shared

Activity by Year

2022-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

E. L. Siegler

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer

C. Manriquez-Roman, E. L. Siegler, J. J. Gleba, T. N. Huynh, G. E. DeFranco, A. Alasonyalilar Demirer, M. L. Pawlush, M. Redig, S. M. Klinge, L. K. Mai, J. L. Miller, E. E. Miller, B. L. Kimball, E. E. Tapper, R. L. Sakemura, , S. S. Kenderian

This paper develops a TSHR-targeted CART cell therapy for thyroid cancer and shows that combining it with MAPK inhibitors improves antitumor efficacy in dedifferentiated thyroid cancers.

bioRxiv · Mar 15, 2024 · PreprintImmunology

Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization

N. Ben-Chetrit, X. Niu, J. Sotelo, A. D. Swett, V. K. Rajasekhar, M. S. Jiao, C. M. Stewart, P. Bhardwaj, S. Kottapalli, S. Ganesan, P.-L. Loyher, C. Potenski, A. Hannuna, K. A. Brown, N. M. Iyengar, , D. A. Landau

This study identifies spatial localization as a key determinant of macrophage heterogeneity and self-renewal in breast cancer, with implications for therapeutic strategies.

bioRxiv · Oct 24, 2023 · PreprintCancer Biology

The Identification of IL-4 as a Regulator of Chimeric Antigen Receptor T Cell Exhaustion

C. M. Stewart, E. L. Siegler, R. L. Sakemura, M. J. Cox, T. Huynh, B. Kimball, L. Mai, I. Can, C. Manriquez Roman, K. Yun, O. Sirpilla, J. H. Girsch, E. Ogbodo, W. Ismail, A. Gaspar-Maia, , S. S. Kenderian

This study identifies IL-4 as a regulator of CART cell exhaustion and shows that IL-4 neutralization improves antitumor efficacy.

bioRxiv · Sep 28, 2023 · PreprintImmunology

Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains

T. N. Starr, A. J. Greaney, C. M. Stewart, A. C. Walls, W. W. Hannon, D. Veesler, J. D. Bloom

This study uses deep mutational scanning to analyze how mutations in the Omicron BA.1 and BA.2 RBDs affect ACE2 binding, RBD folding, and antibody escape, identifying epistatic shifts and lineage-specific changes.

bioRxiv · Sep 20, 2022Microbiology

Sphingosine kinases promote Ebola virus infection and can be targeted to inhibit filoviruses, coronaviruses, and arenaviruses using late endocytic trafficking to enter cells

C. M. Stewart, Y. Bo, K. Fu, M. Chan, R. Kozak, K. Y.-P. Apperley, G. Laroche, A. Beauchemin, G. Kobinger, D. Kobasa, M. Cote

This study shows that sphingosine kinases (SKs) facilitate entry of late-penetrating viruses like Ebola and SARS-CoV-2 by promoting endocytic trafficking, and their inhibition blocks viral entry.

bioRxiv · Aug 12, 2022Microbiology

Female investment in terminal reproduction or somatic maintenance depends on infection dose

N. K. E. Schulz, C. M. Stewart, A. T. Tate

This study shows that female flour beetles adjust reproductive investment based on infection dose, shifting to somatic maintenance at lower doses and trade-off between offspring quality and quantity at higher doses.

bioRxiv · Jul 25, 2022Evolutionary Biology

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

M. Benlarbi, G. Laroche, C. Fink, K. Fu, R. P. Mulloy, A. Phan, A. Ariana, C. M. Stewart, J. Prevost, G. Beaudoin-Bussieres, R. Daniel, Y. Bo, J. Yockell-Lelievre, W. L. Stanford, P. M. Giguere, , M. Cote

This study identifies a MMP2/9-dependent entry pathway for SARS-CoV-2 and variants, showing differential usage and reduced activity in Omicron.

bioRxiv · Feb 19, 2022Microbiology