Author

G. Laroche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell-cell communication· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

M. Cote· 3 shared A. Ariana· 2 shared A. Finzi· 2 shared C. M. Stewart· 2 shared K. Fu· 2 shared P. M. Giguere· 2 shared S. Mubareka· 2 shared Y. Bo· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersMicrobiology

M. Cote

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Sphingosine kinases promote Ebola virus infection and can be targeted to inhibit filoviruses, coronaviruses, and arenaviruses using late endocytic trafficking to enter cells

C. M. Stewart, Y. Bo, K. Fu, M. Chan, R. Kozak, K. Y.-P. Apperley, G. Laroche, A. Beauchemin, G. Kobinger, D. Kobasa, M. Cote

This study shows that sphingosine kinases (SKs) facilitate entry of late-penetrating viruses like Ebola and SARS-CoV-2 by promoting endocytic trafficking, and their inhibition blocks viral entry.

bioRxiv · Aug 12, 2022Microbiology

Highly divergent white-tailed deer SARS-CoV-2 with potential deer-to-human transmission

B. Pickering, O. Lung, F. Maguire, P. Kruczkiewicz, J. D. Kotwa, T. Buchanan, M. Gagnier, J. Guthrie, C. Jardine, A. Marchand-Austin, A. Masse, H. McClinchey, K. Nirmalarajah, P. Aftanas, J. Blais-Savoie, , J. Bowman

The paper identifies a highly divergent SARS-CoV-2 lineage in white-tailed deer with evidence of deer-to-human transmission.

bioRxiv · Feb 22, 2022Microbiology

Identification of a SARS-CoV-2 host metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 and variants of concern Alpha, Delta, and Omicron

M. Benlarbi, G. Laroche, C. Fink, K. Fu, R. P. Mulloy, A. Phan, A. Ariana, C. M. Stewart, J. Prevost, G. Beaudoin-Bussieres, R. Daniel, Y. Bo, J. Yockell-Lelievre, W. L. Stanford, P. M. Giguere, , M. Cote

This study identifies a MMP2/9-dependent entry pathway for SARS-CoV-2 and variants, showing differential usage and reduced activity in Omicron.

bioRxiv · Feb 19, 2022Microbiology

Arsenal of Nanobodies for Broad-Spectrum Countermeasures against Current and Future SARS-CoV-2 Variants of Concerns

M. A. Rossotti, H. van Faassen, A. Tran, J. Sheff, J. A. Sandhu, D. Duque, M. Hewitt, S. Wen, R. Bavananthasivam, S. Beitari, K. Matte, G. Laroche, P. M. Giguere, C. Gervais, M. Stuible, , J. Tanha

This paper presents a diverse set of nanobodies targeting SARS-CoV-2 spike glycoprotein with broad neutralization activity against multiple variants and high in vivo efficacy.

bioRxiv · Dec 20, 2021 · PreprintBioengineering

Bioaffinity-based Surface Immobilization of Antibodies to Capture Endothelial Colony-forming Cells

M. D. Boulanger, M. A. Elkhodiry, O. Bashth, G. Laroche, C. A. Hoesli

This paper develops a bioaffinity-based method to immobilize antibodies on stent surfaces to enhance endothelial cell capture, showing improved antibody concentration and cell capture efficiency compared to traditional methods.

bioRxiv · Jun 23, 2021Bioengineering