K. Yoshimoto

Cyclic mechanical stretching stimuli promotes angiocrine signals during in vitro liver bud formation from human pluripotent stem cells

The paper shows cyclic mechanical stretching enhances angiocrine signals like HGF and MMP9 in co-cultured hepatoblasts and endothelial progenitor cells during liver bud formation from hPSCs.

Non-cell-adhesive hydrogel promotes formation of human blastoid from primed human pluripotent stem cells.

A non-cell-adhesive hydrogel enables blastoid formation from primed hPSC, mimicking blastocyst structure and differentiation.

Use of the Azure Kinect to measure foot clearance during obstacle crossing

This study validates the Azure Kinect as a cost-effective alternative to optical motion capture systems for measuring foot clearance during obstacle crossing, showing high correlation with Qualisys measurements.

Recapitulation of human embryonic heart beating to promote differentiation of hepatic endoderm to hepatoblasts

The paper uses a microfluidic platform to simulate human heart beats, enhancing the functional properties of hepatoblasts derived from hepatic endoderm.

Heat treatment functionalizes hepatocyte-like cells derived from human embryonic stem cells.

This study shows that culturing hepatocyte-like cells from human embryonic stem cells at 39°C improves hepatic functions like albumin secretion and CYP3A4 activity without significant cell death.

Direct synthesis of self-organized blastocyst-like cysts derived from human pluripotent stem cells

The paper describes a method to generate self-organized blastocyst-like cysts from human pluripotent stem cells using a hydrogel matrix and identifies trophoblast and inner cell mass formation.