K.-i. Kamei

Dual-targeted nanoparticulate drug delivery systems for enhancing triple-negative breast cancer treatment

This paper develops a dual-targeted nanoparticulate drug delivery system (SJNP) combining SN38 and JQ-1 to enhance triple-negative breast cancer treatment by disrupting DNA repair and mitochondrial function.

Self-amplifying ROS-sensitive SN38 Dimeric Prodrug nanoparticles for Combined Chemotherapy and Ferroptosis in Cancer Treatment

This paper develops SN38-CA@FC NPs, a ROS-sensitive dimeric prodrug nanoparticle that combines chemotherapy and ferroptosis to treat cancer, showing potent antitumor activity in cell lines and mouse models.

Hybrid Adipocyte-Derived Exosome Nano Platform for Potent Chemo-Phototherapy in Targeted Hepatocellular Carcinoma

This paper develops a hybrid adipocyte-derived exosome platform for targeted chemo-phototherapy of hepatocellular carcinoma, showing enhanced drug delivery and tumor growth inhibition.

SANTA FE OXA: Self-assembled oxaliplatin nanomicelle for enhanced cascade cancer chemotherapy via self-sensitized ferroptosis

This paper develops a nanomicelle, SANTA FE OXA, that enhances cancer chemotherapy by inducing ferroptosis and reducing systemic toxicity.

Modeling dry eye with an air-liquid interface in corneal epithelium-on-a-chip

This study modifies a corneal epithelium-on-a-chip model to simulate dry eye syndrome by applying an air-liquid interface stimulus and assesses its effects with and without diclofenac.

Brain organoid-on-a-chip to create multiple domains in forebrain organoids

This paper introduces a Brain Organoid-on-a-Chip platform that generates signaling gradients to create topographic forebrain organoids, mimicking human brain regions for neurodevelopment and disease studies.

Cyclic mechanical stretching stimuli promotes angiocrine signals during in vitro liver bud formation from human pluripotent stem cells

The paper shows cyclic mechanical stretching enhances angiocrine signals like HGF and MMP9 in co-cultured hepatoblasts and endothelial progenitor cells during liver bud formation from hPSCs.

Non-cell-adhesive hydrogel promotes formation of human blastoid from primed human pluripotent stem cells.

A non-cell-adhesive hydrogel enables blastoid formation from primed hPSC, mimicking blastocyst structure and differentiation.

Gut-liver-axis microphysiological system for studying cellular fluidic shear stress and inter-tissue interaction

This paper introduces a gut-liver-axis microphysiological system that applies physiologically relevant fluid shear stress to gut and liver cells, enhancing their survival and functional protein expression.

An efficient simplified method for the generation of corneal epithelial cells from human pluripotent stem cells

This paper introduces a simplified small molecule-based method to generate functional corneal epithelial cells from human pluripotent stem cells, showing improved differentiation and metabolic characteristics.

Generation of iPSCs from endangered Grevy's zebra and comparative transcriptomic analysis of mammalian PSCs

This study generates iPSCs from Grevy's zebra and compares their transcriptome to other mammalian PSCs, revealing evolutionary conservation and species-specific variation in pluripotency genes.

Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration

This study identifies a bi-phasic effect of gelatin on skeletal muscle regeneration through ROS-mediated signaling, showing low-dose gelatin promotes regeneration while high-dose inhibits it.

Evaluation of solvents used for fabrication of microphysiological systems

This study evaluates solvent use in microphysiological systems fabrication, showing that solvent bonding harms cell cultures while photobonding avoids these issues.

Spatiotemporal Determination of Metabolite Activities in Multiple Corneal Epithelium Barriers on a Chip

This study introduces Cornea-Chip to analyze spatiotemporal metabolite dynamics in corneal epithelium barriers using metabolomics and mRNA analysis.

In vitro nonalcoholic fatty liver disease model with cyclo-olefin-polymer-based microphysiological systems

This paper develops a COP-MPS in vitro model to study NAFLD by preventing FFA absorption, showing lipid accumulation and cell inactivation in HepaRG cells.

Untargeted LC-MS metabolomics for the analysis of micro-scaled extracellular metabolites from hepatocytes

The paper develops an LC-MS-based untargeted metabolomics protocol to analyze micro-scale extracellular metabolites from hepatocytes and identifies metabolite shifts over time.

Cyclo olefin polymer-based solvent-free mass-productive microphysiological systems

The paper develops a cyclo olefin polymer-based microphysiological system to improve drug screening and toxicological testing by avoiding material-related issues.

Integrated gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease

The paper develops a gut-liver-on-a-chip platform to model NAFLD and shows co-culturing gut and liver cells alters gene expression and lipid accumulation in response to free fatty acids.

Recapitulation of human embryonic heart beating to promote differentiation of hepatic endoderm to hepatoblasts

The paper uses a microfluidic platform to simulate human heart beats, enhancing the functional properties of hepatoblasts derived from hepatic endoderm.

Genetic signatures of evolution of the pluripotency gene regulating network across mammals

The paper analyzes the evolution of the pluripotency gene regulatory network across mammals, finding conservation in signaling pathways and rapid evolution in downstream targets.

Heat treatment functionalizes hepatocyte-like cells derived from human embryonic stem cells.

This study shows that culturing hepatocyte-like cells from human embryonic stem cells at 39°C improves hepatic functions like albumin secretion and CYP3A4 activity without significant cell death.

Multi-corneal barriers-on-a-chip to recapitulate eye blinking shear stress forces

This paper develops a microfluidic platform to simulate eye blinking shear stress on human corneal epithelial cells, showing enhanced barrier function under flow conditions.

Direct synthesis of self-organized blastocyst-like cysts derived from human pluripotent stem cells

The paper describes a method to generate self-organized blastocyst-like cysts from human pluripotent stem cells using a hydrogel matrix and identifies trophoblast and inner cell mass formation.

Three-dimensional cultured Liver-on-a-Chip with mature hepatocyte-like cells derived from human pluripotent stem cells

This paper develops a simple Liver-on-a-Chip platform using hPSC-derived hepatocyte-like cells, showing improved hepatic function and maturation.

Genetic Signatures of Lipid Metabolism Evolution in Cetacea

This study identifies 18 positively selected genes in cetaceans related to lipid metabolism, showing divergent evolution from bovids and highlighting pathways involved in lipid digestion and energy production.