T. Adachi

Meis1 isoform diversity orchestrates neural progenitor differentiation by regulating ATOH1 degradation at distinct subcellular compartments

The paper identifies functionally antagonistic Meis1 isoforms that regulate ATOH1 degradation through distinct subcellular localization and E3 ligase interactions, affecting neural progenitor differentiation.

Age-associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex

The paper examines age-related changes in nuclear shape dynamics in excitatory neurons of the visual cortex using time-lapse imaging and finds reduced morphological dynamics in aged nuclei.

Cyclic mechanical stretching stimuli promotes angiocrine signals during in vitro liver bud formation from human pluripotent stem cells

The paper shows cyclic mechanical stretching enhances angiocrine signals like HGF and MMP9 in co-cultured hepatoblasts and endothelial progenitor cells during liver bud formation from hPSCs.

The cholesterol pathway of the Golgi stress response induces cell death and transcription of Golgi-related genes through metabolic dysregulation of phosphatidylinositol-4-phosphate

Migrating neurons adapt motility modes to brain microenvironments via a mechanosensor, PIEZO1

The paper shows cerebellar granule neurons switch migratory modes in 3D environments using PIEZO1 to generate contractile forces.

Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel.

The paper introduces a photocurable hydrogel that allows spatial control of stiffness to direct human pluripotent stem cell differentiation and pattern formation.

Antibacterial 3D-printed PMMA/ceramic composites

This paper investigates 3D-printed PMMA/ceramic composites with antibacterial properties, finding that aluminum nitride provides the best dispersion and antibacterial effect against E. coli.

Cell-fate decision of mesenchymal stem cells toward osteocyte differentiation is committed by cell condensed condition in spheroid culture

This study shows that 3D spheroid culture of hMSCs under osteogenesis conditions leads to osteocyte-like differentiation, mediated by actin balancing in a condensed cell state.

Rapid Inactivation of SARS-CoV-2 by Silicon Nitride, Copper, and Aluminum Nitride

This study shows that silicon nitride, aluminum nitride, and copper inactivate SARS-CoV-2 by >99% within one minute, with silicon nitride being the most effective without causing cell damage.

Propofol induces metabolic reprogramming and cell death in a mitochondrial electron transport chain-dependent manner

This study shows propofol causes metabolic reprogramming and cell death by impairing mitochondrial function, specifically complexes I and III, and this effect is exacerbated by preexisting mitochondrial dysfunction.