Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis
Lakra Promila, Kabita Sarkar, Shivika Guleria, Adrija Rakshit, Manisha Rathore, Nishakumari C Singh, Shaziya Khan, Manendra Singh Tomar, Veena Ammanathan, Manoj Kumar Barthwal, Jagavelu Kumaravelu, Ashutosh Shrivastava, Kalyan Mitra, Rajdeep Guha, Amita Aggarwal, Amit Lahiri
This study shows that inhibiting the mitochondrial calcium uniporter reduces fibroblast-like synoviocytes migration and mitochondrial dysfunction in rheumatoid arthritis.
Free Radical Biology and Medicine · Apr 6, 2025Peer-reviewedImmunology