Manoj Kumar Barthwal

Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis

This study shows that inhibiting the mitochondrial calcium uniporter reduces fibroblast-like synoviocytes migration and mitochondrial dysfunction in rheumatoid arthritis.

MicroRNA-27a is a key modulator of cholesterol biosynthesis

This study identifies miR-27a as a regulator of Hmgcr and cholesterol biosynthesis, showing its role in modulating plasma cholesterol levels in mice.

Hypoxia mediated regulation of mitochondrial transcription factors: Implications of hypertensive renal physiology

This study investigates how hypoxia regulates mitochondrial transcription factors in hypertensive rats and cultured kidney cells, finding increased expression of HIF-1, PGC-1, mtTFs, and OXPHOS proteins under hypoxic conditions.

Functional promoter polymorphisms govern the differential expression of HMG-CoA Reductase gene in rat models of essential hypertension

The paper identifies promoter polymorphisms in the Hmgcr gene that reduce its expression in rat hypertension models by altering transcription factor binding.