Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid-protein interaction sites by mass spectrometry
Luisa M. Welp, Alexander Wulf, Aleksandar Chernev, Yehor Horokhovskyi, Sergei A. Moshkovskii, Olexandr Dybkov, Piotr Neumann, Martin Pašen, Arslan Siraj, Monika Raabe, Henri Göthert, James L. Walshe, Deliana A Infante, Ana C. de A. P. Schwarzer, Achim Dickmanns, , Henning Urlaub
The paper introduces chemical crosslinking with mass spectrometry and a new search engine, NuXL, to identify nucleic acid-protein crosslinks at amino acid resolution, enhancing structural analysis.
Nucleic Acids Research · Jul 22, 2025Peer-reviewedBiochemistry