Author
Max Planck SocietyORCID 0000-0001-7220-3120Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
James L. Walshe, Moritz Ochmann, Ute Neef…·Patrick Cramer
This study reveals a three-step mechanism of co-transcriptional H3K36 methylation by SETD2 through cryo-EM structures and functional analysis.
Karishma Patel, Biswaranjan Mohanty, Alexander R. Norman…·Joel P. Mackay
The paper identifies cyclic peptides that selectively inhibit BET BD paralogues by exploiting sequence differences and conformational dynamics, achieving high selectivity over existing inhibitors.
Luisa M. Welp, Alexander Wulf, Aleksandar Chernev…·Henning Urlaub
The paper introduces chemical crosslinking with mass spectrometry and a new search engine, NuXL, to identify nucleic acid-protein crosslinks at amino acid resolution, enhancing structural analysis.
Alexander O. Ward, Nicole Schönrock, Alex J. McCann…·Richard Paul Harvey
The paper investigates NKX2-5 mutations in congenital heart disease by analyzing their epigenomic, biochemical, and chromatin search functions in cardiomyocytes, revealing diverse loss and gain-of-function defects.