Sergei A. Moshkovskii

This study identifies novel protein-protein interactions of PMP22 using optimized co-immunoprecipitation and mass spectrometry across multiple cell types.

The paper introduces chemical crosslinking with mass spectrometry and a new search engine, NuXL, to identify nucleic acid-protein crosslinks at amino acid resolution, enhancing structural analysis.

The paper reanalyzes proteomic datasets to identify ADAR-mediated RNA editing events and finds 18 core recoded protein sites across human tissues.

The paper validates amino acid variants in proteogenomics by using multiple reads from overlapping peptides to improve variant reliability.

The paper identifies ADAR-mediated RNA editing sites in Drosophila proteomes across developmental stages and shows editing is phase-specific and enriched in synaptic and actomyosin functions.