Early-life mucosal T cells direct intestinal stem cell fate via a coordinated developmental program
Madison S. Strine, Kalida Gawon, Long Phan, Weihong Gu, Wenjia Wang, Hanshu Yuan, Dhana Llivichuzhca-Loja, Kerri St. Denis, Eduardo G. Gonzalez Santiago, Jiaze Liu, Daniel Zeve, David T. Breault, George Tseng, Liza Konnikova
This study shows that early-life mucosal T cells promote intestinal stem cell renewal and secretory differentiation through direct interactions and signaling, with impaired function in NEC and adult T cells.
bioRxiv · May 13, 2026 · PreprintImmunology