Weihong Gu

The Human Gut Cell Atlas v1.0: A Unified, Community-Built Reference of Cellular Diversity Across the Gut

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

Early-life mucosal T cells direct intestinal stem cell fate via a coordinated developmental program

This study shows that early-life mucosal T cells promote intestinal stem cell renewal and secretory differentiation through direct interactions and signaling, with impaired function in NEC and adult T cells.

Poor sleep impairs immune responses and influenza vaccine protection

Poor sleep weakens both the magnitude and quality of immune responses, compromising the protective efficacy of influenza vaccination.

Detection of serotonin and serotonin related gene reveals unique roles in human intestinal epithelial development

The paper identifies serotonin and related gene expression patterns in human intestinal development using single-cell transcriptomics, revealing cell-type-specific roles in gut development.

Excessive immune responses in preterm placental villi compromise trophoblast health

The paper examines immune cell composition and function in placental villi, finding that excessive T cells and cytokines in preterm cases impair trophoblast health.