A class act: HDAC1-Malat1 regulates MDSC apoptosis and cell cycling to decrease suppression of T cells
Aaron G. Baugh, Yingtong Liu, Edgar Gonzalez, Batul Al-Zubeidy, Mukund Iyer, Alex Lee, Nana Gyabaah-Kessie, Matthew B. Jacobo, Cheol H. Park, Jesse Kreger, Lori Khatchaturian, Sabrina K. Zhong, Kaliya Acevedo, Saul J. Priceman, Josh Neman, , Evanthia T. Roussos Torres
The paper shows HDAC1 inhibition in MDSCs increases Malat1, decreases pSTAT3, induces apoptosis and cell cycle arrest, and reduces T cell suppression.
bioRxiv · Mar 25, 2026 · PreprintImmunology