A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells
Marcella Brescia, James Gallant, Andrea Chatrian, Paul Keselman, Elsa Sorman Paulsson, Mervyn P.H. Mol, Rickard Sjögren, Karine Raymond, Valeria V. Orlova, Kalpana Barnes, Richard Wales, Jonas Austerjost, Michael W. Olszowy, Christine L. Mummery, Berend J. van Meer, Richard P. Davis
This study shows that endothelial cells enhance doxorubicin-induced cardiotoxicity in co-cultures with cardiomyocytes, challenging the focus on cardiomyocytes alone.
Stem Cell Reports · Feb 12, 2026Peer-reviewedPharmacology & Toxicology