Richard P. Davis

STRAIGHT-IN Dual enables efficient, single-copy integration of two DNA payloads into hiPSCs, improving genetic engineering for synthetic biology applications.

The paper shows that gene syntax influences supercoiling-mediated transcriptional feedback, affecting adjacent gene expression in human cells.

This study shows that endothelial cells enhance doxorubicin-induced cardiotoxicity in co-cultures with cardiomyocytes, challenging the focus on cardiomyocytes alone.

This study develops scalable 3D cardiac microtissues for high-throughput drug screening, showing reproducible drug responses and identifying 17 drugs that rescue arrhythmic phenotypes.

The paper develops a tunable in vitro model to study ALK1's role in HHT by inducing ALK1 in ACVRL1-null hiPSC-derived endothelial cells, showing threshold-dependent restoration of endothelial function.