Author

James Gallant

Leiden University Medical CenterORCID 0000-0001-6083-5171Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Christine L. MummeryiD· 2 shared Richard P. DavisiD· 2 shared Valeria V. OrlovaiD· 2 shared Albert Blanch-AsensioiD· 1 shared Andrea Chatrian· 1 shared Babet van der VaartiD· 1 shared Berend J. van MeeriD· 1 shared Christian M.A.H. FreundiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

Christine L. MummeryORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyStem Cell ReportsPeer-reviewedFeb 12, 2026

A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells

Marcella Brescia, James Gallant, Andrea Chatrian…·Richard P. Davis

This study shows that endothelial cells enhance doxorubicin-induced cardiotoxicity in co-cultures with cardiomyocytes, challenging the focus on cardiomyocytes alone.

3 citationstop 1%

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintAug 22, 2025

Controlled Induction of ALK1 in ACVRL1-null hiPSC-derived Endothelial Cells Provides Insight into Organ-Restricted AVMs in HHT

Sebastiaan J. van Kampen, Albert Blanch-Asensio, James Gallant…·Valeria V. Orlova

The paper develops a tunable in vitro model to study ALK1's role in HHT by inducing ALK1 in ACVRL1-null hiPSC-derived endothelial cells, showing threshold-dependent restoration of endothelial function.

1 citation

humanbulk RNA-seq

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