Author

Marcella Brescia

Leiden University Medical CenterORCID 0000-0002-0410-1605Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Christine L. MummeryiD· 2 shared Valeria V. OrlovaiD· 2 shared Andrea Chatrian· 1 shared Berend J. van MeeriD· 1 shared Elsa Sorman Paulsson· 1 shared Francijna E. van den HiliD· 1 shared Gopala Krishna Yakala· 1 shared Hailiang MeiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPharmacology & Toxicology

Christine L. MummeryORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyStem Cell ReportsPeer-reviewedFeb 12, 2026

A simplified co-culture reveals altered cardiotoxic responses to doxorubicin in hPSC-derived cardiomyocytes in the presence of endothelial cells

Marcella Brescia, James Gallant, Andrea Chatrian…·Richard P. Davis

This study shows that endothelial cells enhance doxorubicin-induced cardiotoxicity in co-cultures with cardiomyocytes, challenging the focus on cardiomyocytes alone.

3 citationstop 1%

humanbulk RNA-seq

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Developmental BiologyStem CellsPeer-reviewedDec 12, 2022

ETV2 upregulation marks the specification of early cardiomyocytes and endothelial cells during co-differentiation

Xu Cao, Maria Mircea, Gopala Krishna Yakala…·Valeria V. Orlova

The paper identifies ETV2 dynamics in hiPSC-derived cardiac lineages using single-cell RNA-seq and a fluorescent reporter, revealing distinct subpopulations for endothelial and cardiomyocyte specification.

4 citations

humanscRNA-seq

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