Author

Kalyan Dulla

ProQR Therapeutics (Netherlands)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:multiome· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

Gerard J. PlatenburgiD· 2 shared Wouter BeumeriD· 2 shared Andrew R. WebsteriD· 1 shared Cathaline den Besten· 1 shared Davide PiccoloiD· 1 shared Erik de VriezeiD· 1 shared Erwin van WijkiD· 1 shared Hanka VenselaariD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Gerard J. PlatenburgORCID

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2 papers

Recent·Most cited

Antisense oligonucleotide therapy for the common Stargardt disease type 1-causing variant in ABCA4

Melita Kaltak, Petra de Bruijn, Davide Piccolo, Sang-Eun Lee, Kalyan Dulla, Thomas Hoogenboezem, Wouter Beumer, Andrew R. Webster, Rob W.J. Collin, Michael E. Cheetham, Gerard J. Platenburg, Jim Swildens

This study demonstrates that antisense oligonucleotides can correct splicing defects in the ABCA4 c.5461-10T>C variant, restoring protein function in retinal organoids.

bioRxiv · Aug 12, 2022 · PreprintMolecular Biology

Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations

Kalyan Dulla, Ralph W. N. Slijkerman, Hester C. van Diepen, Sílvia Albert, Margo Dona, Wouter Beumer, Janne J. Turunen, Hee Lam Chan, Iris A. E. Schulkens, Lars Vorthoren, Cathaline den Besten, Levi C.M. Buil, Iris Schmidt, Jiayi Miao, Hanka Venselaar, , Erwin van Wijk

This study demonstrates that QR-421a induces exon 13 skipping in USH2A transcripts, restoring retinal function in zebrafish and non-human primates.

Molecular Therapy · Apr 23, 2021Peer-reviewedGenetics