Phosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids
Bitna Lim, Mohamed Nadhir Djekidel, Yurika Matsui, Seung‐Hyun Jung, Zuo‐Fei Yuan, Xusheng Wang, Xiaoyong Yang, Abbas Shirinifard, Haitao Pan, Fang Wang, Shondra M. Pruett‐Miller, Kanisha Kavdia, Vishwajeeth Pagala, Yiping Fan, Junmin Peng, , Jamy C. Peng
This study shows that ATM-mediated phosphorylation of 53BP1-serine 25 is essential for neural progenitor cell proliferation and neuronal differentiation in cortical organoids.
bioRxiv · May 4, 2023 · PreprintDevelopmental Biology