Vishwajeeth Pagala

Lineage-mixed neurodevelopmental programs in pediatric sarcomas nominate tumor-selective surface antigen pairs.

This paper develops an AI framework to interpret single-cell RNA-seq data from pediatric solid tumors, identifying tumor-specific surface antigen pairs for targeted therapies.

Ground Truth-Based Evaluation of False Discovery Rate and Statistical Power in DIA Proteomics

This study evaluates false discovery rate and statistical power in DIA proteomics using technical replicates and spike-in experiments, revealing discrepancies between nominal and true FDR and showing power dependence on fold change and abundance.

APOE is a presynaptic protein that accumulates with age and modulates neurotransmitter release

This study identifies APOE as a presynaptic protein enriched in aged female mice, showing it modulates neurotransmitter release and affects synaptic function.

Linear ubiquitin chains remodel the proteome and influence the levels of hundreds of regulators in Drosophila

The paper investigates how linear ubiquitin chains affect the proteome in Drosophila by analyzing proteomic changes in flies expressing chains of different lengths.

Phosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids

This study shows that ATM-mediated phosphorylation of 53BP1-serine 25 is essential for neural progenitor cell proliferation and neuronal differentiation in cortical organoids.