NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates
Damien Glon, Quentin Riller, Lucı́a Álvarez, Louise Gioja, Frédéric Rivière, Benjamin Léonardon, Zackie Aktary, Ariane Guillemot, Laïla Sago, Olivier Pellé, Nhat-Duong Ho, Karine Brochard, Camille Brunaud, Luís Seabra, Gillian Rice, , Yves Gaudin
This study shows NAP1 switches from enhancing to limiting TBK1 activity through condensate formation, affecting IFN induction and linking to interferonopathies.
Nature Communications · Aug 19, 2026Peer-reviewedImmunology