Author

Luís Seabra

InsermORCID 0000-0002-4678-3026Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Alice LepelleyiD· 3 shared Yanick Joseph CrowiD· 3 shared Gillian RiceiD· 2 shared Adham SafieddineiD· 1 shared Alexandre BélotiD· 1 shared Alexandre Pierga· 1 shared Andreas FellasiD· 1 shared Angie FawkesiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersImmunology

Alice LepelleyORCID

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3 papers

Recent·Most cited

ImmunologyNature CommunicationsPeer-reviewedOct 8, 2026

ATRX Deficiency Drives Aberrant Type I Interferon Signalling Through cGAS-Dependent Transcriptional Dysregulation

Marie‐Thérèse El‐Daher, Eve L. White, Andreas Fellas…·Yanick Joseph Crow

This study identifies ATRX deficiency as a driver of aberrant type I interferon signaling via cGAS-dependent transcriptional dysregulation in patients with cerebral white matter disease.

2 citationstop 4%

humanDNA methylation

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ImmunologyNature CommunicationsPeer-reviewedAug 19, 2026

NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates

Damien Glon, Quentin Riller, Lucı́a Álvarez…·Yves Gaudin

This study shows NAP1 switches from enhancing to limiting TBK1 activity through condensate formation, affecting IFN induction and linking to interferonopathies.

DOI 10.1038/s41467-026-76769-w

humanproteomics

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Cell BiologybioRxivPreprintMay 7, 2026

Loss of MTPAP disrupts mitochondrial RNA processing causing upregulation of type I interferon signalling

Alexandre Pierga, Yan de Souza Angelo, Adham Safieddine…·Alice Lepelley

This study shows that MTPAP loss causes mitochondrial RNA processing defects, leading to type I interferon signaling upregulation through mt-dsRNA accumulation.

DOI 10.64898/2026.05.04.722669

humanmetagenomics

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