A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture
Jasmin Coulombe‐Huntington, Thierry Bertomeu, Caroline Huard, Andrew Chatr‐aryamontri, Daniel J. St‐Cyr, María Sánchez‐Osuna, David J. Papadopoli, Karine Normandin, Mohammadjavad Paydar, Shannon McLaughlan, Corinne St‐Denis, Li Zhang, Henry Say, Roger Palou, Chris Stark, , Mike Tyers
The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.
bioRxiv · Jan 30, 2026 · PreprintSystems Biology