María Sánchez‐Osuna

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

A Saccharomyces boulardii synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation

This paper develops a Saccharomyces boulardii platform for producing and delivering therapeutic nanobodies to treat gastrointestinal inflammation in mice.

PRMT5 is required for full-length HTT expression by repressing multiple proximal intronic polyadenylation sites

This paper identifies PRMT5 as a regulator of HTT mRNA splicing and alternative polyadenylation, showing that its inhibition reduces full-length HTT protein levels by promoting premature termination and cleavage.