Roger Palou

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

Engineered spermidine-secreting Saccharomyces boulardii improves olfactory memory in Drosophila without affecting locomotion.

This paper designs potent small protein inhibitors of C. difficile toxin B using deep learning and Rosetta, showing high affinity and stability for potential clinical use.

This study engineers S. boulardii to secrete spermidine, showing improved efficacy in reducing colitis and colon cancer in mice compared to wild-type strains.

This paper develops a Saccharomyces boulardii platform for producing and delivering therapeutic nanobodies to treat gastrointestinal inflammation in mice.