Almer M. van der Sloot

The paper presents a chemical-genetic interaction matrix derived from CRISPR/Cas9 screens, revealing drug mechanisms and genetic architecture in human cells.

This study engineers S. boulardii to secrete spermidine, showing improved efficacy in reducing colitis and colon cancer in mice compared to wild-type strains.

This paper develops a Saccharomyces boulardii platform for producing and delivering therapeutic nanobodies to treat gastrointestinal inflammation in mice.

This paper introduces AMPLIFY, a protein language model that achieves better performance with less training cost by improving data quality and architecture, challenging the need for scaling.