Full-length transcriptomics and proteomics reveal how genome minimization reshapes gene expression in synthetic bacteria
Enguang Fu, Troy A. Brier, Jason E. Cournoyer, Sage Glass, Yang-le Gao, Yanbao Yu, Zane R. Thornburg, Karrie C. Goglin, Gavin John, Tiana Mamaghani, Sujata Shivakumar, Abner T. Apsley, Christopher J. Fields, Angad P. Mehta, John I. Glass, Zan Luthey-Schulten
The paper characterizes RNA and protein expression in synthetic bacteria Syn1.0 and Syn3A, showing genome minimization alters gene expression and resource allocation.
bioRxiv · Sep 10, 2026 · PreprintSynthetic Biology